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課程名稱 |
藥品動態學
Pharmacokinetics |
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開課學期 |
111-1 |
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授課對象 |
醫學院 藥學研究所 |
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授課教師 |
林君榮 |
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課號 |
PHARM7005 |
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課程識別碼 |
423 M0400 |
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班次 |
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學分 |
2.0 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期三9,10(16:30~18:20) |
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上課地點 |
水森415 |
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備註 |
與余秀瑛、胡幼圃、林淑文、何蘊芳合授
總人數上限：20人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
Advance Pharmacokinetics is a continued course for Biopharmaceutics and Pharmacokinetics. The major purpose of this course is to teach students how to solve pharmacokinetic or pharmacodynamic problems using mathematical approaches. Some of the information and concepts from mathematics and elementary pharmacokinetics will be reviewed or developed as needed, but the balance of prerequisite material will be the student’s responsibility. Readings and homework will be assigned, or may be suggested to improve the learning efficiency of students. |
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課程目標 |
Several topics will be introduced and elaborated in this course: Compartment Models; Pharmacokinetic / Pharmacodynamic (PK/PD) models; Physiological models; Nonlinear Pharmacokinetics; Absorption kinetics; Noncompartmental analysis;
Population pharmacokinetics. |
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課程要求 |
It is important to develop an independent ability to construct pharmacokinetic (PK) and/or pharmacodynamic (PD) models corresponding to situations encountered in research and clinical study. |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
Gibaldi and Perrier, Pharmacokinetics, 1982
Wagner, Fundamental of clinical pharmacokinetics, 1975
Rowland and Tozer, Clinical pharmacokinetics, 1995
Guterman and Nitecki, Differential equations, 1992
In addition to the recommended texts above, readings from other books, review articles or the primary scientific literature may be assigned or recommended by each instructor. Some of the faculty may also provide handout notes as a guide or supplement to their lectures. |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
09/07 |
Compartment Models and Laplace Transform |
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第2週 |
09/14 |
PK/PD Modeling |
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第3週 |
09/21 |
Pharmacometric software (影片觀看) |
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第4週 |
09/28 |
Brief Introduction of R (影片觀看) |
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第5週 |
10/05 |
PK/PD prediction for protein therapeutics(影片觀看) |
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第6週 |
10/12 |
PBPK and Simcyp Applications |
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第7週 |
10/19 |
Application of LC/MS/MS in Pharmacokinetic Study and Drug Development |
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第8週 |
10/26 |
期中考 |
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第9週 |
11/02 |
Population Pharmacokinetics |
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第10週 |
11/09 |
Plasma Concentration vs Tissue Distribution: Analysis of Plasma Protein Binding Interaction |
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第11週 |
11/16 |
Elucidate Contradictory Clinical Reports about Drug Elimination and Effect on Serum Bilirubin Level |
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第12週 |
11/23 |
PK/PD of Antibiotics and Monte Carlo simulation |
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第13週 |
11/30 |
Noncompartmental Analysis |
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第14週 |
12/07 |
Application of R in Pharmacometrics (影片觀看) |
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第15週 |
12/14 |
Absorption kinetics |
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第16週 |
12/21 |
期末考 |
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